WebSULF2 expression unlike SULF1 also spread to the calcifying matrix around the hypertrophic chondrocytes indicating its possible ligand inhibiting role through HSPG desulphation. Higher levels of SULF2 in both developing and healing bone closely correlated with parallel increases in hedgehog signalling analysed by ptc1 receptor expression.", Web28 Oct 2010 · Dai et al. (2005) transfected a human myeloma cell line with SULF1 or SULF2 and found that both enzymes removed 6-O-sulfates from trisulfated disaccharides on the cell surface. The overall levels of 6-O monosulfated and 6-O disulfated disaccharides were not significantly affected. Expression of SULF1 or SULF2 decreased FGF2 signaling, as ...
SULF2 protein expression summary - The Human Protein …
Web29 Mar 2024 · Heparan sulfate proteoglycans (HSPGs) at the cell membrane and extracellular matrix regulate ligand availability and interaction with a range of key … Web16 Apr 2024 · vascular development [15]. Sulfatase 2 (SULF2) is an extracellular enzyme that selectively removes 6-O sulfate groups from HS chains on HSPG molecules [16]. An important role of SULF2 in post-prandial regulation of serum triglycerides has been described, whereas a role of SULF2 in angiogenesis by modifying VEGFA binding to … theo slade
SULF2 Gene - Somatic Mutations in Cancer
Web6 Aug 2015 · SULF2 gene expression is also significantly positively correlated with PDGFRα expression . Furthermore, the ablation of SULF2 decreases tumor growth, prolongs host survival and decreases the activity of PDGFR α , as well as related downstream signaling pathways in human and mouse malignant gliomas [ 99 ]. Web26 Aug 2024 · Sulfatase 2 (SULF2) is a heparan sulfate editing enzyme that regulates the milieu of growth factors and cytokines involved in a variety of cellular processes. We used a murine model of diet-induced steatohepatitis to assess the effect of SULF2 downregulation on the development of nonalcoholic steatohepatitis (NASH) and liver fibrosis. WebSULF2. Synonyms. KIAA1247. ORF names. UNQ559/PRO1120. Organism names. Organism. Homo sapiens (Human) Taxonomic identifier. 9606 NCBI. Taxonomic lineage. Eukaryota > … shubb 12-string guitar capo - nickel finish