Paracellin
WebFHHNC results from mutations in paracellin-1, a tight-junction protein that appears to be important in conducting or regulating paracellular cation transport. Impaired function of paracellin-1 leads specifically to urinary losses of magnesium and calcium, but because … WebParacellin-1 is critical for magnesium and calcium reabsorption addition, the study supports a selective physiological effect of in the human thick ascending limb of Henle. basolateral Mg 21 and Ca 1 concentration on TAL divalent Background. A new protein, named paracellin 1 (PCLN-1), cation paracellular permeability, that is, PCLN-1 activity.
Paracellin
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WebJul 2, 1999 · In a lovely dance between clinical and basic science, the report by Simon et al. now reveals that paracellin-1 regulates the resorption of Mg 2+ through paracellular channels in the kidney tubule. Unlike other ions such as Na +, K +, and Ca 2+, which …
WebHypokalemia can result from insufficient dietary potassium intake, intracellular shifting of potassium from the extracellular space, or potassium loss (renal or extra-renal) ( Table 21–3 ). Genetic disorders can be associated with some electrolyte disturbances ( eTable 21–1 ). A low dietary potassium intake is usually not sufficient as the ... WebFeb 13, 2007 · Paracellin-1 (claudin-16), encoded by the PCLN-1 gene, was a key player in paracellular Mg 2+ reabsorption in the thick ascending limb (TAL) and was found to play an important role in the Mg 2+ renal handling [ 3]. Prolonged ciclosporin (CsA) usage is associated with the development of lower serum Mg 2+ levels.
WebA new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of magnesium and calcium reabsorption, since mutations of PCLN-1 are present in the hypomagnesemia hypercalciuria syndrome (HHS). However, no functional experiments have demonstrated that TAL ... WebCLDN16. Claudin-16 is a protein that in humans is encoded by the CLDN16 gene. [5] [6] It belongs to the group of claudins . Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving …
WebNov 1, 2006 · Paracellin-1 (claudin-16) is a renal tight junction protein encoded by the CLDN16 gene [].It is a key player in magnesium and calcium reabsorption in the thick ascending limb of Henle’s loop [].Mutations in CLDN16 gene lead to familial …
WebAug 1, 2007 · a Detection of paracellin-1 transcripts in human salivary glands by RT-PCR. A Gl. submandibularis, C Gl. parotis, E Gl. labialis, G Gl. sublingualis; B, D, F, H controls lacking reverse transcriptase. black angus chocolate cake recipeWebMay 1, 2006 · Although paracellin-1 (PCLN-1) is known to have a crucial role in the control of Mg 2+ reabsorption in the kidney, the molecular pathways involved in the regulation of PCLN-1 have not been clarified. We used FLAG-tagged PCLN-1 to investigate these pathways further, and found that PCLN-1 is phosphorylated at Ser217 by protein kinase … black angus cheesy garlic bread recipeWebg limb of Henle's loop. Mutations in PCLN-1, which encodes the renal tight junction protein paracellin-1 (claudin-16), were identified as the underlying genetic defects. Comprehensive clinical data and the results of PCLN-1 mutation analysis of 25 FHHNC families with 33 affected individuals are presented. Patients presented mainly with urinary tract infections, … black angus columbus ohioWebtermed paracellin-1 (PCLN-1), was determined (14) and sequence analysis showed that it en-codes a protein of 305 amino acids (Fig. 2A) with four transmembrane domains and intracel-lular NH 2 - and COOH-termini (11, 15). The PCLN-1 protein shows sequence and struc-tural similarity to members of the claudin family (Fig. 2A) (15, 16) and is the most black angus choice beef country style ribsWebtermed paracellin-1 (PCLN-1), was determined (14) and sequence analysis showed that it en-codes a protein of 305 amino acids (Fig. 2A) with four transmembrane domains and intracel-lular NH 2 - and COOH-termini (11, 15). The PCLN-1 protein shows sequence … black angus container robstown txWebg limb of Henle's loop. Mutations in PCLN-1, which encodes the renal tight junction protein paracellin-1 (claudin-16), were identified as the underlying genetic defects. Comprehensive clinical data and the results of PCLN-1 mutation analysis of 25 FHHNC families with 33 … gain city delivery chargesWebBACKGROUND: A new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of magnesium and calcium reabsorption, since mutations of PCLN-1 are present in the … gain city digital innovations pte ltd