WebNov 4, 2024 · Its important functions in protein synthesis endows eIF3 complex with a prominent role in tumorigenesis. The overexpression of eIF3 complex subunits including eIF3a, eIF3b, eIF3c, eIF3h and eIF3i individually promotes the malignant transformation of fibroblast cells by stimulating global protein synthesis and the translation of specific … WebMar 29, 2024 · In addition to participation in nearly every step of the canonical cap-dependent translation initiation as described above, eIF3 may also be involved in controlling other processes of protein synthesis including elongation, termination, and quality control in both positive and negative modes (12).Furthermore, eIF3 subunits may also have …
8664 - Gene ResultEIF3D eukaryotic translation initiation factor 3 ...
WebThe largest of these initiation factors, the eIF3 complex, organizes a web of interactions among several eIFs that assemble on the 40S subunit and participate in the different reactions involved in translation. ... Structural analysis suggests that eIF3 performs this scaffolding function by binding to the 40S subunit on its solvent-exposed ... WebApr 13, 2024 · This review discusses the functions of the m6A modification on RNAs, its role in cancer cell metabolic pathways, the possible underlying mechanisms of its effects and the implication of this modification in cancer therapy. ... Eukaryotic initiation factor 3 (eIF3) is an essential component for initiating cap-independent translation under basal ... east 5th street manhattan
eIF3 SpringerLink
WebJul 27, 2016 · eIF3-specialized translation requires recognition of an internal RNA ... suggesting the apparent 5′ end recognition activity of eIF3d is an evolutionarily preserved function of the eIF3 ... WebFunction. RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis ( PubMed: 17581632, PubMed: 25849773 ). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and ... WebNot all m6A readers are YTH containing; they also include eukaryotic initiation factor 3 (eIF3), heterogeneous nuclear ribonucleoproteins (HNRNPs), and insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs). eIF3 plays a role in translation preinitiation and has also been confirmed to bind preferentially to m6A within the 5'UTR of mRNA … east 5th secretly slender pants